SSX2 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human SSX2 full-length ORF ( AAH02818, 1 a.a. - 223 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MNGDDAFARRPTVGAQIPEKIQKAFDDIAKYFSKEEWEKMKASEKIFYVYMKRKYEAMTKLGFKATLPPFMCNKRAEDFQGNDLDNDPNRGNQVERPQMTFGRLQGISPKIMPKKPAEEGNDSEEVPEASGPQNDGKELCPPGKPTTSEKIHERSGNREAQEKEERRGTAHRWSSQNTHNIGRFSLSTSMGAVHGTPKTITHNRDPKGGNMPGPTDCVRENSW
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
50.27
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SSX2
Entrez GeneID
6757GeneBank Accession#
BC002818Protein Accession#
AAH02818Gene Name
SSX2
Gene Alias
HD21, HOM-MEL-40, MGC119055, MGC15364, MGC3884, SSX
Gene Description
synovial sarcoma, X breakpoint 2
Omim ID
300192Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000024290|OTTHUMP00000024291|sarcoma, synovial, X-chromosome-related 2|synovial sarcoma, X breakpoint 2, isoform b|synovial sarcoma, X breakpoint 2B
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Interactome
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Publication Reference
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Antitumor effect of recombinant Mycobacterium smegmatis expressing MAGEA3 and SSX2 fusion proteins.
Jian W, Li X, Kang J, Lei Y, Bai Y, Xue Y.
Experimental and Therapeutic Medicine 2018 Sep; 16(3):2160.
Application:Func, WB-Re, Mouse, Blood, Tumors.
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Expression and Immunotherapeutic Targeting of the SSX Family of Cancer-Testis Antigens in Prostate Cancer.
Smith HA, Cronk RJ, Lang JM, McNeel DG.
Cancer Research 2011 Nov; 71(21):6785.
Application:IHC-P, WB-Re, Human, Human testis tissues.
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Antitumor effect of recombinant Mycobacterium smegmatis expressing MAGEA3 and SSX2 fusion proteins.
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