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Last updated: 2017/4/23

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SSRP1 rabbit monoclonal antibody

  • Catalog # : H00006749-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human SSRP1 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human SSRP1 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human SSRP1 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 6749
  • GeneBank Accession#:
  • SSRP1
  • Gene Name:
  • SSRP1
  • Gene Alias:
  • FACT,FACT80,T160
  • Gene Description:
  • structure specific recognition protein 1
  • Gene Summary:
  • The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq
  • Other Designations:
  • chromatin-specific transcription elongation factor 80 kDa subunit,cisplatin-DNA SSRP,facilitates chromatin remodeling 80 kDa subunit,high mobility group box,recombination signal sequence recognition protein
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