SSB monoclonal antibody (M01), clone 1D6-H5
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant SSB.
Immunogen
SSB (AAH01289, 1 a.a. ~ 408 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (77); Rat (77)
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (70.62 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
SSB monoclonal antibody (M01), clone 1D6-H5 Western Blot analysis of SSB expression in HL-60 ( Cat # L014V1 ).Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to SSB on formalin-fixed paraffin-embedded human tonsil tissue. [antibody concentration 5 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SSB is 10 ng/ml as a capture antibody.ELISA
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Gene Info — SSB
Entrez GeneID
6741GeneBank Accession#
BC001289Protein Accession#
AAH01289Gene Name
SSB
Gene Alias
LARP3, La
Gene Description
Sjogren syndrome antigen B (autoantigen La)
Omim ID
109090Gene Ontology
HyperlinkGene Summary
La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).[supplied by OMIM
Other Designations
La ribonucleoprotein domain family, member 3|SS-B/La protein|autoantigen La
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Interactome
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Pathway
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Disease
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Publication Reference
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Phosphorylation of human La protein at Ser 366 by casein kinase II contributes to hepatitis B virus replication and expression in vitro.
Tang J, Zhang ZH, Huang M, Heise T, Zhang J, Liu GL.
Journal of Viral Hepatitis 2013 Jan; 20(1):24.
Application:IHC-P, Human, Human liver.
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Akt phosphorylation of La regulates specific mRNA translation in glial progenitors.
Brenet F, Socci ND, Sonenberg N, Holland EC.
Oncogene 2009 Jan; 28(1):128.
Application:WB, Human, Glial progenitors.
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Phosphorylation of human La protein at Ser 366 by casein kinase II contributes to hepatitis B virus replication and expression in vitro.
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