SRD5A2 monoclonal antibody (M01), clone 1F4
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant SRD5A2.
Immunogen
SRD5A2 (NP_000339.2, 28 a.a. ~ 65 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
AKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (64); Rat (67)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (29.81 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SRD5A2 is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — SRD5A2
Entrez GeneID
6716GeneBank Accession#
NM_000348Protein Accession#
NP_000339.2Gene Name
SRD5A2
Gene Alias
MGC138457
Gene Description
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Gene Ontology
HyperlinkGene Summary
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq
Other Designations
3-oxo-5 alpha-steroid 4-dehydrogenase 2|steroid 5-alpha-reductase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Resistance training restores muscle sex steroid hormone steroidogenesis in older men.
Sato K, Iemitsu M, Matsutani K, Kurihara T, Hamaoka T, Fujita S.
FASEB Journal 2014 Apr; 28(4):1891.
Application:WB-Ti, Human, Muscle.
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Resistance training restores muscle sex steroid hormone steroidogenesis in older men.
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