SRD5A2 polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant SRD5A2.
Immunogen
SRD5A2 (NP_000339.2, 28 a.a. ~ 65 a.a) partial recombinant protein with GST tag.
Sequence
AKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (64); Rat (67)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (30.18 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — SRD5A2
Entrez GeneID
6716GeneBank Accession#
NM_000348Protein Accession#
NP_000339.2Gene Name
SRD5A2
Gene Alias
MGC138457
Gene Description
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Gene Ontology
HyperlinkGene Summary
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq
Other Designations
3-oxo-5 alpha-steroid 4-dehydrogenase 2|steroid 5-alpha-reductase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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DHEA Administration Activates Local Bioactive Androgen Metabolism in Cancellous Site of Tibia of Ovariectomized Rats.
Park JH, Aizawa K, Iemitsu M, Sato K, Akimoto T, Agata U, Maeda S, Ezawa I, Omi N.
Calcified Tissue International 2011 Aug; 89(2):105.
Application:WB-Ti, Rat, Rat trabecular bone.
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DHEA Administration Activates Local Bioactive Androgen Metabolism in Cancellous Site of Tibia of Ovariectomized Rats.
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