SPR purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human SPR protein.
Immunogen
SPR (AAH17310.1, 1 a.a. ~ 261 a.a) full-length human protein.
Sequence
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of SPR expression in transfected 293T cell line (H00006697-T01) by SPR MaxPab polyclonal antibody.
Lane1:SPR transfected lysate(28.71 KDa).
Lane2:Non-transfected lysate.
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Gene Info — SPR
Entrez GeneID
6697GeneBank Accession#
NM_003124.3Protein Accession#
AAH17310.1Gene Name
SPR
Gene Alias
SDR38C1
Gene Description
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
Omim ID
182125Gene Ontology
HyperlinkGene Summary
This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq
Other Designations
short chain dehydrogenase/reductase family 38C, member 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Novel Interaction of Ornithine Decarboxylase with Sepiapterin Reductase Regulates Neuroblastoma Cell Proliferation.
Lange I, Geerts D, Feith DJ, Mocz G, Koster J, Bachmann AS.
Journal of Molecular Biology 2014 Jan; 426(2):332.
Application:IF, WB-Ce, WB-Tr, Human, MYCN2 NB, HEK 293 cells.
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Novel Interaction of Ornithine Decarboxylase with Sepiapterin Reductase Regulates Neuroblastoma Cell Proliferation.
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