SPAST monoclonal antibody (M01), clone 3A12
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More Files
- More Functions
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SPAST is approximately 0.1ng/ml as a capture antibody.
Western Blot detection against Immunogen (37.29 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant SPAST.
Immunogen
SPAST (NP_055761, 200 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (88); Rat (79)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.29 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SPAST is approximately 0.1ng/ml as a capture antibody.ELISA
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Gene Info — SPAST
Entrez GeneID
6683GeneBank Accession#
NM_014946Protein Accession#
NP_055761Gene Name
SPAST
Gene Alias
ADPSP, FSP2, KIAA1083, SPG4
Gene Description
spastin
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq
Other Designations
OTTHUMP00000158570|spastic paraplegia 4 (autosomal dominant; spastin)
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Interactome
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Disease
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