SOS1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human SOS1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human SOS1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human SOS1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — SOS1
Entrez GeneID
6654GeneBank Accession#
SOS1Gene Name
SOS1
Gene Alias
GF1, GGF1, GINGF, HGF, NS4
Gene Description
son of sevenless homolog 1 (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq
Other Designations
OTTHUMP00000128306|gingival fibromatosis, hereditary, 1|guanine nucleotide exchange factor|son of sevenless homolog 1
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