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SORL1 Pre-design Chimera RNAi

  • Catalog # : H00006653-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens processed pseudogene mtTFA 3 (LOC260339) on chromosome 6.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_003105
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 6653
  • Gene Name:
  • SORL1
  • Gene Alias:
  • C11orf32,FLJ21930,FLJ39258,LR11,LRP9,SORLA,SorLA-1,gp250
  • Gene Description:
  • sortilin-related receptor, L(DLR class) A repeats-containing
  • Gene Summary:
  • This gene encodes a protein that belongs to the families of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins, of low density lipoprotein receptor (LDLR) proteins, and of fibronectin type III repeats proteins. In addition to VPS10, LDLR and fibronectin type 3 domains, this protein also includes an epidermal growth factor precursor-like module, a single transmembrane segment and a cytoplasmic tail with features similar to endocytosis- and sorting-competent receptors. Members of the VPS10 domain-containing receptor family are large with many exons but the CDS lengths are usually less than 3700 nt; this gene is an exception to the pattern with a CDS length greater than 6600 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. The encoded protein is mainly intracellular and localizes in the paranuclear compartment. It is synthesized as a preproprotein, and when the propeptide is still attached, no binding occurs to the VPS10 domain. This gene is strongly expressed in the central nervous system. [provided by RefSeq
  • Other Designations:
  • mosaic protein LR11,sortilin-related receptor containing LDLR class A repeats
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