Western blot analysis of SNX1 over-expressed 293 cell line, cotransfected with SNX1 Validated Chimera RNAi ( Cat # H00006642-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with SNX1 monoclonal antibody (M01), clone 6H1 (Cat # H00006642-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq