SNRPN 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-SNRPN full-length
Host
Human
Theoretical MW (kDa)
26.51
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-SNRPN antibody (H00006638-B01) by Western Blots.
SDS-PAGE Gel
SNRPN transfected lysate
Western Blot
Lane 1: SNRPN transfected lysate ( 26.51 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — SNRPN
Entrez GeneID
6638GeneBank Accession#
BC003180Protein Accession#
AAH03180Gene Name
SNRPN
Gene Alias
DKFZp686C0927, DKFZp686M12165, DKFZp761I1912, DKFZp762N022, FLJ33569, FLJ36996, FLJ39265, HCERN3, MGC29886, PWCR, RT-LI, SM-D, SMN, SNRNP-N, SNURF-SNRPN
Gene Description
small nuclear ribonucleoprotein polypeptide N
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq
Other Designations
OTTHUMP00000159463|SM protein N|tissue-specific splicing protein
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Interactome
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Disease
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