SMPD1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human SMPD1 partial ORF ( NP_000534.3, 531 a.a. - 630 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
AIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLF
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Interspecies Antigen Sequence
Mouse (82); Rat (83)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SMPD1
Entrez GeneID
6609GeneBank Accession#
NM_000543Protein Accession#
NP_000534.3Gene Name
SMPD1
Gene Alias
ASM, NPD
Gene Description
sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
acid sphingomyelinase
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Interactome
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Pathway
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Disease
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