SMARCD3 monoclonal antibody (M01), clone 1G6
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant SMARCD3.
Immunogen
SMARCD3 (NP_001003801, 385 a.a. ~ 483 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
ISALDSKIHETIESINQLKIQRDFMLSFSRDPKGYVQDLLRSQSRDLKVMTDVAGNPEEERRAEFYHQPWSQEAVSRYFYCKIQQRRQELEQSLVVRNT
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (100); Rat (100)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
SMARCD3 monoclonal antibody (M01), clone 1G6 Western Blot analysis of SMARCD3 expression in K-562 ( Cat # L009V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SMARCD3 is approximately 0.3ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to SMARCD3 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — SMARCD3
Entrez GeneID
6604GeneBank Accession#
NM_001003801Protein Accession#
NP_001003801Gene Name
SMARCD3
Gene Alias
BAF60C, CRACD3, MGC111010, Rsc6p
Gene Description
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Omim ID
601737Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq
Other Designations
60kDa BRG-1/Brm associated factor subunit c|SWI/SNF complex 60 kDa subunit C|SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, isoform 1|Swp73-like protein|chromatin remodeling complex BAF60C subunit|mammal
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Interactome
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Publication Reference
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Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors.
Hartung S, Schwanke K, Haase A, David R, Franz WM, Martin U, Zweigerdt R.
Stem Cells and Development 2013 Apr; 22(7):1112.
Application:IF, Human, hCBiPS2.
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Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy.
Zhang Z, Alpert D, Francis R, Chatterjee B, Yu Q, Tansey T, Sabol SL, Cui C, Bai Y, Koriabine M, Yoshinaga Y, Cheng JF, Chen F, Martin J, Schackwitz W, Gunn TM, Kramer KL, De Jong PJ, Pennacchio LA, Lo CW.
PNAS 2009 Mar; 106(9):3219.
Application:IF, Mouse, MEFs.
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The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor.
Flajollet S, Lefebvre B, Cudejko C, Staels B, Lefebvre P.
Molecular and Cellular Endocrinology 2007 Feb; 270(1-2):23.
Application:WB, Mouse, P19CL6 cells.
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Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors.
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