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SLC12A3 Pre-design Chimera RNAi

  • Catalog # : H00006559-R01
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Homo sapiens solute carrier family 12 (sodium/chloride transporters), member 3 (SLC12A3), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_000339
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 6559
  • Gene Name:
  • SLC12A3
  • Gene Alias:
  • FLJ96318,NCCT,TSC
  • Gene Description:
  • solute carrier family 12 (sodium/chloride transporters), member 3
  • Gene Summary:
  • This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • Na-Cl symporter,NaCl electroneutral thiazide-sensitive cotransporter,sodium-chloride cotransporter, thiazide-sensitive,solute carrier family 12, member 3,thiazide-sensitive Na-Cl cotransporter
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