SLC12A1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human SLC12A1 full-length ORF ( ENSP00000331550, 1 a.a. - 430 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRISFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEALRKQGASPLPQGAQSRRRRQTSLI
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
72.9
Interspecies Antigen Sequence
Rat (92)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SLC12A1
Entrez GeneID
6557GeneBank Accession#
ENST00000330289Protein Accession#
ENSP00000331550Gene Name
SLC12A1
Gene Alias
BSC1, MGC48843, NKCC2
Gene Description
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
Gene Ontology
HyperlinkGene Summary
The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. [provided by RefSeq
Other Designations
NKCC2A variant A|Na-K-2Cl cotransporter|sodium potassium chloride cotransporter 2
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Interactome
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Disease
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