SHMT2 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human SHMT2 protein.
Immunogen
SHMT2 (NP_005403.2, 1 a.a. ~ 504 a.a) full-length human protein.
Sequence
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDEH
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
SHMT2 MaxPab polyclonal antibody. Western Blot analysis of SHMT2 expression in human spleen.Western Blot (Cell lysate)
SHMT2 MaxPab polyclonal antibody. Western Blot analysis of SHMT2 expression in HeLa.Western Blot (Transfected lysate)
Western Blot analysis of SHMT2 expression in transfected 293T cell line (H00006472-T02) by SHMT2 MaxPab polyclonal antibody.
Lane 1: SHMT2 transfected lysate(55.44 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to SHMT2 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — SHMT2
Entrez GeneID
6472GeneBank Accession#
NM_005412.4Protein Accession#
NP_005403.2Gene Name
SHMT2
Gene Alias
GLYA, SHMT
Gene Description
serine hydroxymethyltransferase 2 (mitochondrial)
Omim ID
138450Gene Ontology
HyperlinkOther Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Nathalie Escande-Beillard, Abigail Loh, Sahar N Saleem, Kohei Kanata, Yui Hashimoto, Umut Altunoglu, Artina Metoska, Joanes Grandjean, Fui Mee Ng, Oz Pomp,Nithya Baburajendran, Joyner Wong, Jeffrey Hill, Emmanuel Beillard, Patrick Cozzone, Maha Zaki, Hülya Kayserili, Hiroshi Hamada, Hidetaka Shiratori, Bruno Reversade.
Neuron 2020 Apr; S0896.
Application:IF, IHC-P, WB, Human, Mouse, Human primary dermal fibroblasts, Mouse brains.
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Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
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