FBXW4 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-FBXW4 full-length
Host
Human
Theoretical MW (kDa)
45.43
Interspecies Antigen Sequence
Mouse (93); Rat (94)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-FBXW4 antibody (H00006468-B01) by Western Blots.
SDS-PAGE Gel
FBXW4 transfected lysate.
Western Blot
Lane 1: FBXW4 transfected lysate ( 45.43 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — FBXW4
Entrez GeneID
6468GeneBank Accession#
NM_022039Protein Accession#
NP_071322Gene Name
FBXW4
Gene Alias
DAC, FBW4, FBWD4, SHFM3, SHSF3
Gene Description
F-box and WD repeat domain containing 4
Gene Ontology
HyperlinkGene Summary
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq
Other Designations
F-box and WD-40 domain protein 4|F-box/WD repeat protein 4|OTTHUMP00000059175|dactylin
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