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FBXW4 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00006468-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-FBXW4 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 45.43
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-FBXW4 antibody (H00006468-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00006468-T01
    FBXW4 transfected lysate.
    Western Blot
    QC Testing of H00006468-T01
    Lane 1: FBXW4 transfected lysate ( 45.43 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 6468
  • Gene Name:
  • FBXW4
  • Gene Alias:
  • DAC,FBW4,FBWD4,SHFM3,SHSF3
  • Gene Description:
  • F-box and WD repeat domain containing 4
  • Gene Summary:
  • This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq
  • Other Designations:
  • F-box and WD-40 domain protein 4,F-box/WD repeat protein 4,OTTHUMP00000059175,dactylin
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