Immunoprecipitation of SGCG transfected lysate using anti-SGCG MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with SGCG purified MaxPab mouse polyclonal antibody (B01P) (H00006445-B01P).
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq