SDC1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human SDC1 full-length ORF ( NP_001006947.1, 1 a.a. - 310 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHQASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
58.9
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SDC1
Entrez GeneID
6382GeneBank Accession#
NM_001006946.1Protein Accession#
NP_001006947.1Gene Name
SDC1
Gene Alias
CD138, SDC, SYND1, syndecan
Gene Description
syndecan 1
Omim ID
186355Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq
Other Designations
CD138 antigen|OTTHUMP00000115942|heparan sulfate proteoglycan fibroblast growth factor receptor|syndecan proteoglycan 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation.
Christopher T Turner, Matthew R Zeglinski, Wendy Boivin, Hongyan Zhao, Megan A Pawluk, Katlyn C Richardson, Arundhasa Chandrabalan, Phillip Bird, Rithwik Ramachandran, Roma Sehmi, Hermenio Lima, Gail Gauvreau, David J Granville.
The British Journal of Dermatology 2022 Oct; ljac017.
Application：Sub, Recombinant proteins, Recombinant proteins.
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Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation.
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