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Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

SCP2

Gene Alias

DKFZp686C12188, DKFZp686D11188, NLTP, NSL-TP, SCPX

Gene Description

sterol carrier protein 2

Omim ID

Gene Ontology

Gene Summary

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq

Other Designations

OTTHUMP00000010488|nonspecific lipid-transfer protein|sterol carrier protein X