SCNN1A rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human SCNN1A peptide using ARM Technology.
Immunogen
A synthetic peptide of human SCNN1A is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human SCNN1A peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — SCNN1A
Entrez GeneID
6337GeneBank Accession#
SCNN1AGene Name
SCNN1A
Gene Alias
ENaCa, ENaCalpha, FLJ21883, SCNEA, SCNN1
Gene Description
sodium channel, nonvoltage-gated 1 alpha
Gene Ontology
HyperlinkGene Summary
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
alpha ENaC-2|amiloride-sensitive epithelial sodium channel alpha subunit|nasal epithelial sodium channel alpha subunit
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