SCN8A (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human SCN8A partial ORF ( NP_055006, 1854 a.a. - 1951 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
RVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVT
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.52
Interspecies Antigen Sequence
Mouse (98); Rat (96)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SCN8A
Entrez GeneID
6334GeneBank Accession#
NM_014191Protein Accession#
NP_055006Gene Name
SCN8A
Gene Alias
CerIII, MED, NaCh6, Nav1.6, PN4
Gene Description
sodium channel, voltage gated, type VIII, alpha subunit
Omim ID
600702Gene Ontology
HyperlinkGene Summary
Voltage-dependent sodium channels, such as SCN8A, are responsible for the initial membrane depolarization that occurs during generation of action potentials in most electrically excitable cells (Plummer et al., 1998 [PubMed 9828131]).[supplied by OMIM
Other Designations
hNa6/Scn8a voltage-gated sodium channel|motor endplate disease|sodium channel voltage-gated type VIII alpha|sodium channel, voltage gated, type VIII, alpha|sodium channel, voltage gated, type VIII, alpha polypeptide|voltage-gated sodium channel Nav1.6|vol
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Interactome
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Disease
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