S100A6 monoclonal antibody (M16), clone 6D1
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant S100A6.
Immunogen
S100A6 (NP_055439, 18 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
KYSGREGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMEDLDRNKDQEVNFQEYVTFLGALALIYSEALKG
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (94); Rat (93)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (33.77 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
S100A6 monoclonal antibody (M16), clone 6D1 Western Blot analysis of S100A6 expression in HeLa ( Cat # L013V1 ).Western Blot (Transfected lysate)
Western Blot analysis of S100A6 expression in transfected 293T cell line by S100A6 monoclonal antibody (M16), clone 6D1.
Lane 1: S100A6 transfected lysate(10.2 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged S100A6 is approximately 0.03ng/ml as a capture antibody.ELISA
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Gene Info — S100A6
Entrez GeneID
6277GeneBank Accession#
NM_014624Protein Accession#
NP_055439Gene Name
S100A6
Gene Alias
2A9, 5B10, CABP, CACY, PRA
Gene Description
S100 calcium binding protein A6
Omim ID
114110Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq
Other Designations
OTTHUMP00000015472|OTTHUMP00000015473|S100 calcium-binding protein A6|S100 calcium-binding protein A6 (calcyclin)|calcyclin|prolactin receptor-associated protein
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Interactome
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Disease
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Publication Reference
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Cancer-Initiating Cells from Colorectal Cancer Patients Escape from T Cell-Mediated Immunosurveillance In Vitro through Membrane-Bound IL-4.
Volonte A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, Bissolati M, Ghirardelli L, Orsenigo E, Ferrone S, Doglioni C, Stassi G, Dellabona P, Staudacher C, Parmiani G, Maccalli C.
The Journal of Immunology 2014 Jan; 192(1):523.
Application:IF-CCCC, Human, Cancer-initiating cells from colorectal cancer.
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S100A6 Overexpression Associates with Poor Prognosis and Is Epigenetically Up-Regulated in Gastric Cancer.
Wang XH, Zhang LH, Zhong XY, Xing XF, Liu YQ, Niu ZJ, Peng Y, Du H, Zhang GG, Hu Y, Liu N, Zhu YB, Ge SH, Zhao W, Lu AP, Li JY, Ji JF.
The American Journal of Pathology 2010 Aug; 177(2):586.
Application:IEM, IF, IHC-P, WB-Ce, WB-Ti, Human, Human gastric cancer, AGS, BGC823, KATO3, MKN45, RF1, RF48, SGC7901 cells.
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Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients.
Di Tomaso T, Mazzoleni S, Wang E, Sovena G, Clavenna D, Franzin A, Mortini P, Ferrone S, Doglioni C, Marincola FM, Galli R, Parmiani G, Maccalli C.
Clinical Cancer Research 2010 Feb; 16(3):800.
Application:Flow Cyt, Human, Cancer stem cells.
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Cancer-Initiating Cells from Colorectal Cancer Patients Escape from T Cell-Mediated Immunosurveillance In Vitro through Membrane-Bound IL-4.
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