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Last updated: 2016/12/4

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RRM1 rabbit monoclonal antibody

  • Catalog # : H00006240-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human RRM1 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human RRM1 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human RRM1 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 6240
  • GeneBank Accession#:
  • RRM1
  • Gene Name:
  • RRM1
  • Gene Alias:
  • R1,RIR1,RR1
  • Gene Description:
  • ribonucleotide reductase M1
  • Gene Summary:
  • This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq
  • Other Designations:
  • ribonucleoside-diphosphate reductase M1 chain,ribonucleotide reductase M1 polypeptide,ribonucleotide reductase, R1 subunit,ribonucleotide reductase, large subunit
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