ROCK1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human ROCK1 partial ORF ( NP_005397, 401 a.a. - 510 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
SNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRR
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (92)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ROCK1
Entrez GeneID
6093GeneBank Accession#
NM_005406Protein Accession#
NP_005397Gene Name
ROCK1
Gene Alias
MGC131603, MGC43611, P160ROCK, PRO0435
Gene Description
Rho-associated, coiled-coil containing protein kinase 1
Omim ID
601702Gene Ontology
HyperlinkGene Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq
Other Designations
OTTHUMP00000162514|p160-ROCK
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Interactome
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Pathway
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Disease
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