Products

Western Blot (Transfected lysate)

Immunofluorescence (Transfected cell)

Flow Cytometry (Transfected cell)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

ABCE1

Gene Alias

ABC38, OABP, RLI, RNASEL1, RNASELI, RNS4I

Gene Description

ATP-binding cassette, sub-family E (OABP), member 1

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

Other Designations

ATP-binding cassette, sub-family E, member 1|RNase L inhibitor|ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor