Immunoprecipitation of RNF6 transfected lysate using anti-RNF6 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with RNF6 MaxPab mouse polyclonal antibody (B01) (H00006049-B01).
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq
OTTHUMP00000018154,OTTHUMP00000018155,OTTHUMP00000018156,RING-H2 protein RNF-6,ring finger protein 6