RFX5 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-RFX5 full-length
Host
Human
Theoretical MW (kDa)
65.3
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-RFX5 antibody (H00005993-D01P) by Western Blots.
SDS-PAGE Gel
RFX5 transfected lysate.
Western Blot
Lane 1: RFX5 transfected lysate ( 65.30 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — RFX5
Entrez GeneID
5993GeneBank Accession#
NM_000449.3Protein Accession#
NP_000440.1Gene Name
RFX5
Gene Alias
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Gene Description
regulatory factor X, 5 (influences HLA class II expression)
Gene Ontology
HyperlinkGene Summary
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq
Other Designations
OTTHUMP00000082795|OTTHUMP00000196318|regulatory factor X, 5
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Interactome
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Pathway
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Disease
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