RET 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-RET full-length
Host
Human
Theoretical MW (kDa)
119.8
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-RET antibody (H00005979-B01) by Western Blots.
SDS-PAGE Gel
RET transfected lysate.
Western Blot
Lane 1: RET transfected lysate ( 119.8 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — RET
Entrez GeneID
5979GeneBank Accession#
BC004257.1Protein Accession#
-Gene Name
RET
Gene Alias
CDHF12, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Gene Description
ret proto-oncogene
Gene Ontology
HyperlinkGene Summary
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq
Other Designations
RET transforming sequence|cadherin family member 12|hydroxyaryl-protein kinase|oncogene RET|receptor tyrosine kinase|ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
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Interactome
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Pathway
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Disease
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