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Last updated: 2016/11/27

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UPF1 monoclonal antibody (M01A), clone 4G3

  • Catalog # : H00005976-M01A
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against a partial recombinant UPF1.
  • Immunogen:
  • UPF1 (NP_002902.2, 1019 a.a. ~ 1116 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
  • Sequence:
  • GRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLS
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Isotype:
  • IgG1 Kappa
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.

    QC Testing of H00005976-M01A
    Western Blot detection against Immunogen (36.52 KDa) .
  • Storage Buffer:
  • In ascites fluid
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Recombinant protein)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 5976
  • Gene Name:
  • UPF1
  • Gene Alias:
  • FLJ43809,FLJ46894,HUPF1,KIAA0221,NORF1,RENT1,pNORF1
  • Gene Description:
  • UPF1 regulator of nonsense transcripts homolog (yeast)
  • Gene Summary:
  • This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq
  • Other Designations:
  • UP Frameshift 1,delta helicase,nonsense mRNA reducing factor 1,regulator of nonsense transcripts 1,up-frameshift mutation 1 homolog,yeast Upf1p homolog
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