RDX monoclonal antibody (M06), clone 1D9
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant RDX.
Immunogen
RDX (AAH47109, 1 a.a. ~ 583 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKEKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (89.87 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
RDX monoclonal antibody (M06), clone 1D9 Western Blot analysis of RDX expression in HeLa ( Cat # L013V1 ).Western Blot (Recombinant protein)
ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to RDX on HeLa cell. [antibody concentration 30 ug/ml] -
Gene Info — RDX
Entrez GeneID
5962GeneBank Accession#
BC047109Protein Accession#
AAH47109Gene Name
RDX
Gene Alias
DFNB24
Gene Description
radixin
Gene Ontology
HyperlinkGene Summary
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. [provided by RefSeq
Other Designations
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Publication Reference
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ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points.
Jocelyn F Krey, Chang Liu, Inna A Belyantseva, Michael Bateschell, Rachel A Dumont, Jennifer Goldsmith, Paroma Chatterjee, Rachel S Morrill, Lev M Fedorov, Sarah Foster, Jinkyung Kim, Alfred L Nuttall, Sherri M Jones, Dongseok Choi, Thomas B Friedman, Anthony J Ricci, Bo Zhao, Peter G Barr-Gillespie.
The Journal of Cell Biology 2022 Apr; 221(4):e20210913.
Application:ICC, Mouse, Mouse hair cells.
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Ca 2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.
Julia Halford, Michael Bateschell, Peter G Barr-Gillespie.
Molecular Biology of the Cell 2022 Apr; 33(4):br6.
Application:PLA, Mouse, Mouse hair cells.
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Radixin modulates the function of outer hair cell stereocilia.
Sonal Prasad, Barbara Vona, Marta Diñeiro, María Costales, Rocío González-Aguado, Ana Fontalba, Clara Diego-Pérez, Asli Subasioglu, Guney Bademci, Mustafa Tekin, Rubén Cabanillas, Juan Cadiñanos, Anders Fridberger.
Communications Biology 2020 Dec; 3(1):792.
Application:IF, IHC, Guinea pig, Guinea pig cochlear hair cells.
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Radixin inhibition decreases adult neural progenitor cell migration and proliferation in vitro and in vivo.
Persson A, Lindberg OR, Kuhn HG.
Frontiers in Cellular Neuroscience 2013 Sep; 7:161.
Application:IF, Rat, Brain.
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Radixin expression in microglia after cortical stroke lesion.
Persson A, Osman A, Bolouri H, Mallard C, Kuhn HG.
Glia 2013 May; 61(5):790.
Application:IHC, Mouse, Mouse brain.
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Molecular architecture of the chick vestibular hair bundle.
Shin JB, Krey JF, Hassan A, Metlagel Z, Tauscher AN, Pagana JM, Sherman NE, Jeffery ED, Spinelli KJ, Zhao H, Wilmarth PA, Choi D, David LL, Auer M, Barr-Gillespie PG.
Nature Neuroscience 2013 Jan; 16(3):365.
Application:IF, Chicken, Hair bundles.
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Large membrane domains in hair bundles specify spatially constricted radixin activation.
Zhao H, Williams DE, Shin JB, Brügger B, Gillespie PG.
Journal of Neuroscience 2012 Mar; 32(13):4600.
Application:ICC, IF, Chicken, Hair bundles.
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ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points.
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