RASA1 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-RASA1 full-length
Host
Human
Theoretical MW (kDa)
100.4
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-RASA1 antibody (H00005921-B01) by Western Blots.
SDS-PAGE Gel
RASA1 transfected lysate.
Western Blot
Lane 1: RASA1 transfected lysate ( 100.4 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — RASA1
Entrez GeneID
5921GeneBank Accession#
NM_022650Protein Accession#
NP_072179Gene Name
RASA1
Gene Alias
CM-AVM, CMAVM, DKFZp434N071, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP
Gene Description
RAS p21 protein activator (GTPase activating protein) 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq
Other Designations
GTPase activating protein|RAS p21 protein activator 1|triphosphatase-activating protein
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Interactome
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