RAP1A (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human RAP1A full-length ORF ( AAH14086.1, 1 a.a. - 184 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
45.98
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — RAP1A
Entrez GeneID
5906GeneBank Accession#
BC014086Protein Accession#
AAH14086.1Gene Name
RAP1A
Gene Alias
KREV-1, KREV1, RAP1, SMGP21
Gene Description
RAP1A, member of RAS oncogene family
Omim ID
179520Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000013740|OTTHUMP00000013741|OTTHUMP00000059089|RAS-related protein RAP1A|Ras-related protein Krev-1|Ras-related protein Rap-1A
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Interactome
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Pathway
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Publication Reference
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Epac Activates the Small G Proteins Rap1 and Rab3A to Achieve Exocytosis.
Branham MT, Bustos MA, De Blas GA, Rehmann H, Zarelli VE, Trevino CL, Darszon A, Mayorga LS, Tomes CN.
The Journal of Biological Chemistry 2009 Sep; 284(37):24825.
Application：Treated, Recombinant protein.
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Rap1b Regulates B Cell Development, Homing, and T Cell-Dependent Humoral Immunity.
Chu H, Awasthi A, White GC 2nd, Chrzanowska-Wodnicka M, Malarkannan S.
Journal of Immunology 2008 Sep; 181(5):3373.
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Epac Activates the Small G Proteins Rap1 and Rab3A to Achieve Exocytosis.
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