RAP1A rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human RAP1A peptide using ARM Technology.
Immunogen
A synthetic peptide of human RAP1A is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human RAP1A peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — RAP1A
Entrez GeneID
5906GeneBank Accession#
RAP1AGene Name
RAP1A
Gene Alias
KREV-1, KREV1, RAP1, SMGP21
Gene Description
RAP1A, member of RAS oncogene family
Omim ID
179520Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000013740|OTTHUMP00000013741|OTTHUMP00000059089|RAS-related protein RAP1A|Ras-related protein Krev-1|Ras-related protein Rap-1A
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