RAG2 (Human) IP-WB Antibody Pair
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Interspecies Antigen Sequence
Mouse (88%); Rat (88%)
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of RAG2 transfected lysate using rabbit polyclonal anti-RAG2 and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-RAG2.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: rabbit polyclonal anti-RAG2 (300 ul)
2. Antibody pair for WB: mouse purified polyclonal anti-RAG2 (50 ug)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
-
Applications
Immunoprecipitation-Western Blot
-
Gene Info — RAG2
Entrez GeneID
5897Gene Name
RAG2
Gene Alias
RAG-2
Gene Description
recombination activating gene 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq
Other Designations
V(D)J recombination-activating protein 2
-
Interactome
-
Pathway
-
Disease
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com