RAD17 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-RAD17 full-length
Host
Human
Theoretical MW (kDa)
66.2
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-RAD17 antibody (H00005884-B01) by Western Blots.
SDS-PAGE Gel
RAD17 transfected lysate.
Western Blot
Lane 1: RAD17 transfected lysate ( 66.2 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — RAD17
Entrez GeneID
5884GeneBank Accession#
NM_133341Protein Accession#
NP_579919Gene Name
RAD17
Gene Alias
CCYC, FLJ41520, HRAD17, R24L, RAD17SP, RAD24
Gene Description
RAD17 homolog (S. pombe)
Omim ID
603139Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000125189|OTTHUMP00000125190|OTTHUMP00000125192|OTTHUMP00000125193|OTTHUMP00000125194|RAD1 homolog|RAD17 homolog|RF-C activator 1 homolog|Rad17-like protein|cell cycle checkpoint protein (RAD17)
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Interactome
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Disease
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