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RAD17 Pre-design Chimera RNAi

  • Catalog # : H00005884-R02
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens RAD17 homolog (S. pombe) (RAD17), transcript variant 1, mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_133338
  • Target Region:
  • Coding sequence
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.
    The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 5884
  • Gene Name:
  • RAD17
  • Gene Alias:
  • CCYC,FLJ41520,HRAD17,R24L,RAD17SP,RAD24
  • Gene Description:
  • RAD17 homolog (S. pombe)
  • Gene Summary:
  • The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000125189,OTTHUMP00000125190,OTTHUMP00000125192,OTTHUMP00000125193,OTTHUMP00000125194,RAD1 homolog,RAD17 homolog,RF-C activator 1 homolog,Rad17-like protein,cell cycle checkpoint protein (RAD17)
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