Products

Western Blot (Cell lysate)

QDPR monoclonal antibody (M02), clone M1 Western Blot analysis of QDPR expression in HL-60 ( Cat # L014V1 ).

Western Blot (Transfected lysate)

Western Blot analysis of QDPR expression in transfected 293T cell line by QDPR monoclonal antibody (M02), clone M1.

Lane 1: QDPR transfected lysate(25.8 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged QDPR is approximately 0.1ng/ml as a capture antibody.

ELISA

RNAi Knockdown (Antibody validated)

Western blot analysis of QDPR over-expressed 293 cell line, cotransfected with QDPR Validated Chimera RNAi ( Cat # H00005860-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with QDPR monoclonal antibody (M02), clone M1 (Cat # H00005860-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.

Entrez GeneID

5860

GeneBank Accession#

BC000576

Protein Accession#

AAH00576

Gene Name

QDPR

Gene Alias

DHPR, FLJ42391, PKU2, SDR33C1

Gene Description

quinoid dihydropteridine reductase

Omim ID

261630

Gene Ontology

Hyperlink

Gene Summary

This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq

Other Designations

6,7-dihydropteridine reductase|short chain dehydrogenase/reductase family 33C, member 1