ALDH18A1 monoclonal antibody (M01), clone 2B5
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More Files
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Western Blot (Cell lysate)
ALDH18A1 monoclonal antibody (M01), clone 2B5 Western Blot analysis of ALDH18A1 expression in MCF-7 ( Cat # L046V1 ).
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ALDH18A1 is 0.3 ng/ml as a capture antibody.
Western Blot detection against Immunogen (36.74 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ALDH18A1.
Immunogen
ALDH18A1 (NP_002851, 696 a.a. ~ 795 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
TDVIVTEDENTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGKDHVVSDFSEHGSLKYLHENLPIPQRNTN
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (96); Rat (94)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
ALDH18A1 monoclonal antibody (M01), clone 2B5 Western Blot analysis of ALDH18A1 expression in MCF-7 ( Cat # L046V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ALDH18A1 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — ALDH18A1
Entrez GeneID
5832GeneBank Accession#
NM_002860Protein Accession#
NP_002851Gene Name
ALDH18A1
Gene Alias
GSAS, MGC117316, P5CS, PYCS
Gene Description
aldehyde dehydrogenase 18 family, member A1
Omim ID
138250Gene Ontology
HyperlinkGene Summary
This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000020159|OTTHUMP00000020160|delta1-pyrroline-5-carboxlate synthetase|glutamate gamma-semialdehyde synthetase|pyrroline-5-carboxlate synthetase|pyrroline-5-carboxylate synthetase|pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde sy
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Interactome
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Pathway
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Disease
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Publication Reference
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Functional specialization in proline biosynthesis of melanoma.
De Ingeniis J, Ratnikov B, Richardson AD, Scott DA, Aza-Blanc P, De SK, Kazanov M, Pellecchia M, Ronai Z, Osterman AL, Smith JW.
PLoS One 2012 Sep; 7(9):e45190.
Application：WB-Ce, Human, Human melanocytes, Melanoma cells.
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Functional specialization in proline biosynthesis of melanoma.
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