Western blot analysis of RAD1 over-expressed 293 cell line, cotransfected with RAD1 Validated Chimera RNAi ( Cat # H00005810-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with RAD1 monoclonal antibody (M01), clone 1G2 (Cat # H00005810-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq
DNA repair exonuclease REC1,OTTHUMP00000115992,RAD1 homolog,Rad1-like DNA damage checkpoint,cell cycle checkpoint protein Hrad1,checkpoint control protein HRAD1,exonuclease homolog RAD1