PTPRJ (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human PTPRJ partial ORF ( NP_002834.2, 38 a.a. - 137 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
GTPSPIPDPSVATVATGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVIL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Interspecies Antigen Sequence
Rat (33)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PTPRJ
Entrez GeneID
5795GeneBank Accession#
NM_002843Protein Accession#
NP_002834.2Gene Name
PTPRJ
Gene Alias
CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
Gene Description
protein tyrosine phosphatase, receptor type, J
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD148 antigen|human density enhanced phosphatase-1|protein tyrosine phosphatase, receptor type, J polypeptide|receptor-type tyrosine-protein phosphatase eta|susceptibility to colon cancer 1, mouse, homolog of
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Interactome
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Disease
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