PTPRF (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human PTPRF full-length ORF ( ENSP00000361488, 1 a.a. - 353 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGGSPIRGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRGKDSGSAWPLSPQSCAAPAGLSAQSPWCRHARDCHGPSLFSFLLLSAAAATAPTGQVPGVCHYFAFLPCRPMGKQPLLGAFVSFVGLAAWARSPMGIWSHPIRLLGVCACVCAHTGTLICV
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
63.7
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PTPRF
Entrez GeneID
5792GeneBank Accession#
ENST00000372411Protein Accession#
ENSP00000361488Gene Name
PTPRF
Gene Alias
FLJ43335, FLJ45062, FLJ45567, LAR
Gene Description
protein tyrosine phosphatase, receptor type, F
Omim ID
179590Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
Other Designations
LCA-homolog|OTTHUMP00000008684|leukocyte antigen-related (LAR) PTP receptor|leukocyte antigen-related tyrosine phosphatase|protein tyrosine phosphatase, receptor type, F polypeptide|receptor-linked protein-tyrosine phosphatase LAR
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Interactome
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Disease
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