Products

Antibody Production

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PTPRE

Gene Alias

DKFZp313F1310, FLJ57799, FLJ58245, HPTPE, PTPE, R-PTP-EPSILON

Gene Description

protein tyrosine phosphatase, receptor type, E

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq

Other Designations

OTTHUMP00000020735|OTTHUMP00000020736|protein tyrosine phosphatase epsilon|protein tyrosine phosphatase, receptor type, epsilon polypeptide