PTPN13 polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant PTPN13.
Immunogen
PTPN13 (NP_006255, 66 a.a. ~ 175 a.a) partial recombinant protein with GST tag.
Sequence
FTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (95); Rat (92)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
ELISA
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Gene Info — PTPN13
Entrez GeneID
5783GeneBank Accession#
NM_006264Protein Accession#
NP_006255Gene Name
PTPN13
Gene Alias
DKFZp686J1497, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE
Gene Description
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Omim ID
600267Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq
Other Designations
APO-1/CD95 (Fas)-associated phosphatase|Fas-associated phosphatase-1|protein tyrosine phosphatase 1E|protein tyrosine phosphatase, non-receptor type 13|protein tyrosine phosphatase, nonreceptor type 13|protein-tyrosine phosphatase 1, Fas-associated|protei
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Interactome
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Disease
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