PTPN12 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
PTPN12 transfected lysate.
Western Blot
Lane 1: PTPN12 transfected lysate ( 85.91 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PTPN12 full-length
Host
Human
Theoretical MW (kDa)
85.91
Interspecies Antigen Sequence
Mouse (84); Rat (84)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PTPN12 antibody (H00005782-B01) by Western Blots.
SDS-PAGE Gel
PTPN12 transfected lysate.
Western Blot
Lane 1: PTPN12 transfected lysate ( 85.91 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PTPN12
Entrez GeneID
5782GeneBank Accession#
NM_002835.2Protein Accession#
-Gene Name
PTPN12
Gene Alias
PTP-PEST, PTPG1
Gene Description
protein tyrosine phosphatase, non-receptor type 12
Omim ID
600079Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000025119|protein-tyrosine phosphatase G1|tyrosine-protein phosphatase non-receptor type 12
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Interactome
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Disease
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