PTPN2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PTPN2 full-length
Host
Human
Theoretical MW (kDa)
45.2
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PTPN2 antibody (H00005771-D01) by Western Blots.
SDS-PAGE Gel
PTPN2 transfected lysate.
Western Blot
Lane 1: PTPN2 transfected lysate ( 45.2 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PTPN2
Entrez GeneID
5771GeneBank Accession#
NM_080422.1Protein Accession#
NP_536347.1Gene Name
PTPN2
Gene Alias
PTPT, TC-PTP, TCELLPTP, TCPTP
Gene Description
protein tyrosine phosphatase, non-receptor type 2
Omim ID
176887Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq
Other Designations
T-cell protein tyrosine phosphatase
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Interactome
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Disease
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