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Last updated: 2016/10/23
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PTPN1 (Human) IP-WB Antibody Pair

  • Catalog # : H00005770-PW1
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  • Specification
  • Product Description:
  • This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Immunoprecipitation-Western Blot (IP-WB)

    QC Testing of H00005770-PW1
    Immunoprecipitation of PTPN1 transfected lysate using rabbit polyclonal anti-PTPN1 and Protein A Magnetic Bead (U0007), and immunoblotted with mouse polyclonal anti-PTPN1.
  • Supplied Product:
  • Antibody pair set content:
    1. Antibody pair for IP: rabbit polyclonal anti-PTPN1 (300 ul)
    2. Antibody pair for WB: mouse polyclonal anti-PTPN1 (50 ul)
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Applications
  • Application Image
  • Immunoprecipitation-Western Blot
  • Gene Information
  • Entrez GeneID:
  • 5770
  • Gene Name:
  • PTPN1
  • Gene Alias:
  • PTP1B
  • Gene Description:
  • protein tyrosine phosphatase, non-receptor type 1
  • Gene Summary:
  • The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000031266,non-receptor tyrosine phosphatase 1,protein tyrosine phosphatase 1B,protein tyrosine phosphatase, placental
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