PTK6 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
PTK6 MaxPab polyclonal antibody. Western Blot analysis of PTK6 expression in human colon.
Western Blot (Transfected lysate)
Western Blot analysis of PTK6 expression in transfected 293T cell line (H00005753-T01) by PTK6 MaxPab polyclonal antibody.
Lane 1: PTK6 transfected lysate(49.61 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to PTK6 on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human PTK6 protein.
Immunogen
PTK6 (NP_005966.1, 1 a.a. ~ 451 a.a) full-length human protein.
Sequence
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (80); Rat (80)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
PTK6 MaxPab polyclonal antibody. Western Blot analysis of PTK6 expression in human colon.Western Blot (Transfected lysate)
Western Blot analysis of PTK6 expression in transfected 293T cell line (H00005753-T01) by PTK6 MaxPab polyclonal antibody.
Lane 1: PTK6 transfected lysate(49.61 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to PTK6 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — PTK6
Entrez GeneID
5753GeneBank Accession#
NM_005975.2Protein Accession#
NP_005966.1Gene Name
PTK6
Gene Alias
BRK, FLJ42088
Gene Description
PTK6 protein tyrosine kinase 6
Omim ID
602004Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. [provided by RefSeq
Other Designations
OTTHUMP00000031656|breast tumor kinase|protein-tyrosine kinase BRK
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Interactome
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Disease
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Publication Reference
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Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling.
Sallam AA, Mohyeldin MM, Foudah AI, Akl MR, Nazzal S, Meyer SA, Liu YY, El Sayed KA.
Organic & Biomolecular Chemistry 2014 Jul; 12(28):5295.
Application：WB-Ce, Human, MDA-MD-231 cells.
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The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling.
Akl MR, Foudah AI, Ebrahim HY, Meyer SA, El Sayed KA.
Marine Drugs 2014 Apr; 12(4):2282.
Application：WB-Ce, Human, MDA-MB-231, MCF-7, BT-474, T-47D cells.
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Optimization, Pharmacophore Modeling and 3D-QSAR Studies of Sipholanes as Breast Cancer Migration and Proliferation Inhibitors.
Foudah AI, Sallam AA, Akl MR, El Sayed KA.
European Journal of Medicinal Chemistry 2014 Feb; 73:310.
Application：WB, Human, MDA-MD-231 cells.
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Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling.
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