PSMD2 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PSMD2 full-length
Host
Human
Theoretical MW (kDa)
99.99
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PSMD2 antibody (H00005708-B01) by Western Blots.
SDS-PAGE Gel
PSMD2 transfected lysate.
Western Blot
Lane 1: PSMD2 transfected lysate ( 99.99 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PSMD2
Entrez GeneID
5708GeneBank Accession#
BC007897Protein Accession#
AAH07897Gene Name
PSMD2
Gene Alias
MGC14274, P97, Rpn1, S2, TRAP2
Gene Description
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Omim ID
606223Gene Ontology
HyperlinkGene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. [provided by RefSeq
Other Designations
26S proteasome non-ATPase regulatory subunit 2|26S proteasome regulatory subunit S2|26S proteasome subunit p97|55.11 protein|TNFR-associated protein 2|proteasome 26S non-ATPase subunit 2|tumor necrosis factor receptor-associated protein 2
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