Products

Western Blot (Recombinant protein)

ELISA

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PSMD1

Gene Alias

MGC133040, MGC133041, P112, Rpn2, S1

Gene Description

proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

Gene Ontology

Gene Summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. [provided by RefSeq

Other Designations

26S proteasome non-ATPase regulatory subunit 1|26S proteasome regulatory subunit S1|26S proteasome subunit p112|proteasome 26S non-ATPase subunit 1